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Dernières publications
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
132
Publications avec texte intégral
Open Access
52 %
Mots clés
Trinucleotide repeat expansion
In vivo
Oligodendrocytes
Centronuclear myopathy
BIOLOGIE MOLECULAIRE
Cardiac muscle
Dynamin 2
Diaphragm
Glial cells
Lc3
Central nervous system
Brain
Thérapie génique
GABA
DMPK
Gene therapy
Antisense oligonucleotide
ARN
Autophagy
Glucocorticoids
Myostatin
Acetylcholinesterase deficiency
Gene editing
RNA biology
CMS
Myelin
Exercise
CRISPRi
Skeletal muscle
Transgenic mouse
ACETYLCHOLINESTERASE
Muscular dystrophy
Glucocorticoid-receptor
Myotonic Dystrophy Type 1
CRISPR/Cas9
Trinucleotide Repeat Expansion
Myotonic Dystrophy type 1
Glutamate
Therapy
Transcriptomics
Quantitative microdialysis
Genotype phenotype correlation
GSK3
Expression
Antisense oligonucleotides
Heart failure
Mice
Alternative splicing
Gene Therapy
CTG repeats
KNOCKOUT MICE
DM1
DMSXL mice
MBNL
Exercice
Long read sequencing
Dilated cardiomyopathy
Aging
Muscle
AAV
PacBio
Cytoskeleton
Brain dysfunction
Astrocytes
Oligodendrocyte
Myotonic dystrophy mouse models
Knockout
Cell penetrating peptide
Intermediate filament
Mouse model
Duchenne muscular dystrophy
RNA splicing
PCR
Male
Dystrophie Myotonique
Mouse models
CTG repeat instability
Maximal force
Hypoxia
Motoneuron
Dystrophie myotonique
CONGENITAL MYATHENIC SYNDROME
Cell culture model
Neuron
CTG repeat contractions
Fibrosis
Astrocyte
Animals
Myotonic dystrophy type 1
Myotonic Dystrophy
Acetylcholinesterase knockout mouse
Heart
Acute coronary syndrome
Myotonic dystrophy
Desmin
Transgenic mouse model
Cell model
Dystrophin
RNA interference
Humans