Enniatins and Beauvericin Emerging Mycotoxins Affect Pigs' Metabolome
Abstract
In addition to deoxynivalenol, fumonisins and zearalenone, Fusarium fungi produce other toxins such as beauvericin or enniatins, which are called “emerging” mycotoxins (EMs). Occurrence data and biological effects for EMs are still limited. Recently, feed ingredients were shown to contain 66% to 98% of beauvericin, enniatin B, aurofusarin or apicidin [1]. In vitro, data suggest that BEA and ENN induce cytotoxicity, oxidative stress and apoptosis. In vivo, while they do not induce apparent acute mycotoxicosis, no conclusion can be drawn on chronic exposure. To study the impact of EMs, we conducted a LC-MS based metabolomics study of plasma and liver of piglets (5 weeks) fed with a mixture of enniatins B, B1 and beauvericin during 14 days.
Domains
Analytical chemistry
Origin : Files produced by the author(s)