Lactate as a determinant of neuronal excitability, neuroenergetics and beyond

Bruno Cauli (1, 2, 3) , Isabelle Dusart (1, 2, 4) , Dongdong Li (1, 2, 5)

1 IBPS - Institut de Biologie Paris Seine
2 NPS - Neuroscience Paris Seine
3 NPS - Réseaux synaptiques et neuroénergétiques = Synaptic and Neuroenegertic Networks
4 NPS - Développement et plasticité des réseaux neuronaux = Development and Plasticity of Neural Networks
5 NPS - Développement de l'organisation spinale = Development of the spinal cord organization

Over the last decades, lactate has emerged as important energy substrate for the brain fueling of neurons. A growing body of evidence now indicates that it is also a signaling molecule modulating neuronal excitability and activity as well as brain functions. In this review, we will briefly summarize how different cell types produce and release lactate. We will further describe different signaling mechanisms allowing lactate to fine-tune neuronal excitability and activity, and will finally discuss how these mechanisms could cooperate to modulate neuroenergetics and higher order brain functions both in physiological and pathological conditions.

Domaines: Sciences du Vivant [q-bio]

Bruno Cauli, Isabelle Dusart, Dongdong Li. Lactate as a determinant of neuronal excitability, neuroenergetics and beyond. Neurobiology of Disease, 2023, Astrocyte metabolism in Neurodegeneration, 184, pp.106207. ⟨10.1016/j.nbd.2023.106207⟩. ⟨hal-04132442⟩