Direct Molecular Diagnosis of Aspergillosis and CYP51A Profiling from Respiratory Samples of French Patients

Yanan Zhao (1) , Cécile Garnaud (2) , Marie-Pierre Brenier-Pinchart (3) , Anne Thiébaut-Bertrand , Christel Saint-Raymond (4) , Boubou Camara , Rebecca Hamidfar (5) , Odile Cognet , Danièle Maubon (6) , Muriel Cornet (2) , David S. Perlin

1 LTSI - Laboratoire de Traitement du Signal et de l'Image
2 TIMC-IMAG-TheREx - Thérapeutique Recombinante Expérimentale
3 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
4 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
5 Unité de Réanimation médicale
6 Institut de Biologie et Pathologie

Conclusion: Direct molecular detection of Aspergillus spp. and azole resistance markers are useful adjunct tools for comprehensive aspergillosis diagnosis. The observed superior diagnostic value of BAs to BAL fluids warrants more in-depth study.

Mots clés: Aspergillus fumigatus; azole resistance; respiratory samples; French patients; CYP51A; molecular diagnostics

Domaines: Mycologie

Yanan Zhao, Cécile Garnaud, Marie-Pierre Brenier-Pinchart, Anne Thiébaut-Bertrand, Christel Saint-Raymond, et al.. Direct Molecular Diagnosis of Aspergillosis and CYP51A Profiling from Respiratory Samples of French Patients. Frontiers in Microbiology, 2016, 7, ⟨10.3389/fmicb.2016.01164⟩. ⟨hal-01470813⟩