The apical 70-pS K + channel in the thick ascending limb of Henle’s loop is a large-conductance Na + -and Cl – -activated, K Na 1.1-like, channel

Le canal potassique de 70 pS sur la membrane apicale de la branche large ascendante de l'anse de Henle est un canal de grande conductance, activé par le Na+ et le Cl- ressemblant à un canal KNa1.1.

Elise de Combiens (1) , Nadia Frachon (1) , Lydie Cheval (1) , Stéphane Lourdel (1) , Marc Paulais (1)

1 Physiologie rénale et tubulopathies = Renal Physiology and tubulopathies [CRC]

This study highlights new regulatory and conductive properties of the as yet poorly molecularly defined 70-pS K + channel in the apical membrane of the thick ascending limb of Henle’s loop cells of the mouse kidney that functionally identify it as a large-conductance, Na + - and Cl – -activated K Na 1.1-like channel.

Keywords: mouse kidney; thick ascending limb; 70-pS K channel; K Na 1.1 channel; ROMK channel

Domains: Life Sciences [q-bio]

Elise de Combiens, Nadia Frachon, Lydie Cheval, Stéphane Lourdel, Marc Paulais. The apical 70-pS K + channel in the thick ascending limb of Henle’s loop is a large-conductance Na + -and Cl – -activated, K Na 1.1-like, channel. American Journal of Physiology. Renal Physiology, 2024, 326 (3), pp.F485-F496. ⟨10.1152/ajprenal.00311.2023⟩. ⟨hal-04556454⟩