Circulating human basophils lack the features of professional antigen presenting cells

Abstract : Recent reports in mice demonstrate that basophils function as antigen presenting cells (APC). They express MHC class II and co-stimulatory molecules CD80 and CD86, capture and present soluble antigens or IgE-antigen complexes and polarize Th2 responses. Therefore, we explored whether human circulating basophils possess the features of professional APC. We found that unlike dendritic cells (DC) and monocytes, steady-state circulating human basophils did not express HLA-DR and co-stimulatory molecules CD80 and CD86. Basophils remained negative for these molecules following stimulation with soluble Asp f 1, one of the allergens of Aspergillus fumigatus; Bet v 1, the major birch allergen; TLR2-ligand or even upon IgE cross-linking. Unlike DC, Asp f 1-pulsed basophils did not promote Th2 responses as analyzed by the secretion of IL-4 in the basophil-CD4+ T cell co-culture. Together, these results demonstrate the inability of circulating human basophils to function as professional APC.
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Scientific Reports, Nature Publishing Group, 2013, 3 (1), pp.1188 〈10.1038/srep01188〉
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Meenu Sharma, Pushpa Hegde, Vishukumar Aimanianda, Remi Beau, Mohan S. Maddur, et al.. Circulating human basophils lack the features of professional antigen presenting cells. Scientific Reports, Nature Publishing Group, 2013, 3 (1), pp.1188 〈10.1038/srep01188〉. 〈hal-01610260〉

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