Skip to Main content Skip to Navigation
Book sections

Functional genomics and molecular networks Gene expression regulations in complex diseases: Down syndrome as a case study

Marie-Claude Potier 1, * Isabelle Rivals 2
* Corresponding author
2 ESA - Equipe de Statistique Appliquée (UMRS 1158)
ESPCI Paris - Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, Neurophysiologie Respiratoire Expérimentale et Clinique : UMRS1158
Abstract : The goal of functional genomics is to understand the relationship be-tween whole genomes and phenotypes through a dynamic approach. It requires high throughput technologies such as microarrays and data analysis. The power of this approach allowed to study complex biological functions as well as diseases. In this chapter, we introduce functional genomics and describe the statistical methods that are used to find differentially expressed genes. We analyze a large num-ber of data sets produced on a complex disease, namely Down syn-drome, in different models. We show that, whatever the model, genes that are in three copies are globally overexpressed. However, we failed to identify a set of two-copy genes that would be dysregu-lated in all studies. It either suggests that studies are incomplete, or that this set of genes does not exist and that overexpression of the three-copy genes impacts on the whole transcriptome in a "stochas-tic" way.
Complete list of metadata

Cited literature [51 references]  Display  Hide  Download

https://hal-espci.archives-ouvertes.fr/hal-00801558
Contributor : Isabelle Rivals Connect in order to contact the contributor
Submitted on : Monday, March 18, 2013 - 3:18:09 PM
Last modification on : Monday, April 26, 2021 - 3:24:13 AM
Long-term archiving on: : Thursday, June 20, 2013 - 3:58:35 PM

File

TS21.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-00801558, version 1
`

Citation

Marie-Claude Potier, Isabelle Rivals. Functional genomics and molecular networks Gene expression regulations in complex diseases: Down syndrome as a case study. N. Le Novère. Computational Systems Neurobiology Textbook, Part I : Functional Genomics and Molecular Networks, Springer, pp.1-22, 2012. ⟨hal-00801558⟩

Share

Metrics

Record views

555

Files downloads

252