Functional genomics and molecular networks Gene expression regulations in complex diseases: Down syndrome as a case study

Abstract : The goal of functional genomics is to understand the relationship be-tween whole genomes and phenotypes through a dynamic approach. It requires high throughput technologies such as microarrays and data analysis. The power of this approach allowed to study complex biological functions as well as diseases. In this chapter, we introduce functional genomics and describe the statistical methods that are used to find differentially expressed genes. We analyze a large num-ber of data sets produced on a complex disease, namely Down syn-drome, in different models. We show that, whatever the model, genes that are in three copies are globally overexpressed. However, we failed to identify a set of two-copy genes that would be dysregu-lated in all studies. It either suggests that studies are incomplete, or that this set of genes does not exist and that overexpression of the three-copy genes impacts on the whole transcriptome in a "stochas-tic" way.
Type de document :
Chapitre d'ouvrage
N. Le Novère. Computational Systems Neurobiology Textbook, Part I : Functional Genomics and Molecular Networks, Springer, pp.1-22, 2012
Liste complète des métadonnées

Littérature citée [51 références]  Voir  Masquer  Télécharger

https://hal-espci.archives-ouvertes.fr/hal-00801558
Contributeur : Isabelle Rivals <>
Soumis le : lundi 18 mars 2013 - 15:18:09
Dernière modification le : mercredi 21 mars 2018 - 18:57:35
Document(s) archivé(s) le : jeudi 20 juin 2013 - 15:58:35

Fichier

TS21.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : hal-00801558, version 1

Collections

Citation

Marie-Claude Potier, Isabelle Rivals. Functional genomics and molecular networks Gene expression regulations in complex diseases: Down syndrome as a case study. N. Le Novère. Computational Systems Neurobiology Textbook, Part I : Functional Genomics and Molecular Networks, Springer, pp.1-22, 2012. 〈hal-00801558〉

Partager

Métriques

Consultations de la notice

409

Téléchargements de fichiers

109