Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation

Alireza Kazemi (1) , Bruno Louis (2) , Daniel Isabey (2) , Gary Nieman , Louis Gatto , Joshua Satalin , Sarah Baker , James B Grotberg (3) , Marcel Filoche (4)

1 DEE - Department of Electrical Engineering
2 U955 Inserm - UPEC - IMRB - "Biomechanics and Respiratory Apparatus" [Créteil]
3 Department of Biomedical Engineering [Ann Arbor, MI, États-Unis]
4 LPMC - Laboratoire de physique de la matière condensée

Surfactant Replacement Therapy (SRT), which involves instillation of a liquid-surfactant mixture directly into the lung airway tree, is a major therapeutic treatment in neonatal patients with respiratory distress syndrome (RDS). This procedure has proved to be remarkably effective in premature newborns, inducing a five-fold decrease of mortality in the past 35 years. Disappointingly, its use in

Domaines: Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]; Matière Molle [cond-mat.soft]; Pneumologie et système respiratoire; Optique / photonique

Alireza Kazemi, Bruno Louis, Daniel Isabey, Gary Nieman, Louis Gatto, et al.. Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation. PLoS Computational Biology, 2019, 15 (10), pp.e1007408. ⟨10.1371/journal.pcbi.1007408⟩. ⟨hal-02360593⟩