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Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation

Abstract : Surfactant Replacement Therapy (SRT), which involves instillation of a liquid-surfactant mixture directly into the lung airway tree, is a major therapeutic treatment in neonatal patients with respiratory distress syndrome (RDS). This procedure has proved to be remarkably effective in premature newborns, inducing a five-fold decrease of mortality in the past 35 years. Disappointingly, its use in
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Submitted on : Monday, January 4, 2021 - 11:22:28 AM
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Alireza Kazemi, Bruno Louis, Daniel Isabey, Gary Nieman, Louis Gatto, et al.. Surfactant delivery in rat lungs: Comparing 3D geometrical simulation model with experimental instillation. PLoS Computational Biology, Public Library of Science, 2019, 15 (10), pp.e1007408. ⟨10.1371/journal.pcbi.1007408⟩. ⟨hal-02360593⟩

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