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Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy

Abstract : Influenza virus infections are major public health threats due to their high rates of morbidity and mortality. Upon influenza virus entry, host cells experience modifications of endomembranes, including those used for virus trafficking and replication. Here we report that influenza virus infection modifies mitochondrial morphodynamics by promoting mitochondria elongation and altering endoplasmic reticulum-mitochondria tethering in host cells. Expression of the viral RNA recapitulates these modifications inside cells. Virus induced mitochondria hyper-elongation was promoted by fission associated protein DRP1 relocalization to the cytosol, enhancing a profusion status. We show that altering mitochondrial hyper-fusion with Mito-C, a novel pro-fission compound, not only restores mitochondrial morphodynamics and endoplasmic reticulum-mitochondria contact sites but also dramatically reduces influenza replication. Finally, we demonstrate that the observed Mito-C antiviral property is directly connected with the innate immunity signaling RIG-I complex at mitochondria. Our data highlight the importance of a functional interchange between mitochondrial morphodynamics and innate immunity machineries in the context of influenza viral infection.
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https://hal.archives-ouvertes.fr/hal-03439550
Contributor : Ivan Mikaelian Connect in order to contact the contributor
Submitted on : Monday, November 22, 2021 - 12:00:09 PM
Last modification on : Wednesday, January 12, 2022 - 12:18:02 PM

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journal.ppat.1009340 (1).pdf
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Irene Pila-Castellanos, Diana Molino, Joe Mckellar, Laetitia Lines, Juliane da Graca, et al.. Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy. PLoS Pathogens, Public Library of Science, 2021, 17, ⟨10.1371/journal.ppat.1009340⟩. ⟨hal-03439550⟩

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