Host-Guest System Based on Collagen-Like Triple-Helix Hybridization

Nicolas Delsuc (1, 2) , Shohei Uchinomiya (3) , Akio Ojida (3) , Itaru Hamachi (4)

1 LBM-E1 - Peptides, glycoconjugués et métaux en biologie
2 Département de Chimie - ENS Paris
3 Graduate School of Pharmaceutical Sciences
4 Department of Synthetic Chemistry and Biological Chemistry

A strategy inspired by tweezer receptors has been employed to develop a new host-guest system. The Hybridization into a collagen-like triple helix is the driving force for the recognition that occurs with high affinity and selectivity. Several systems have been screened to find the best host-guest pair and this strategy may be implemented for tag fused protein recongnition.

Domaines: Chimie thérapeutique

Nicolas Delsuc, Shohei Uchinomiya, Akio Ojida, Itaru Hamachi. Host-Guest System Based on Collagen-Like Triple-Helix Hybridization. Chemical Communications, 2017, 53, pp.6856-6859 ⟨10.1039/C7CC03055J⟩. ⟨hal-01535603⟩