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MAPSSIC, a communicating MAPS-based intracerebral positrons probe for deep brain imaging in awake and freely-moving rats

Abstract : Radioisotope imaging is a powerful tool to understand the biological mechanisms in-vivo, especially in the brain of small animals, providing a significant model to study the human brain.In this context, we have developed and built a pixelated intracerebral positron probe to be embedded on awake and freely moving small animals, typically rats. This pixelated probe will represent a key instrument for neuroscientists to study neural mechanisms and correlate them to behavioral experiments.We describe in this paper the simulations carried out to design the intracerebral sensor, its architecture, and the detection of positrons in a volume with a couple of sensors assembled back-to-back. We also depict the architecture of the wireless acquisition system. Finally, we present the first measurements performed in real-time by this miniaturized probe with sealed radioactive sources and a 18F solution.Key words: Active pixel sensors / Animal behavior / CMOS Image sensors / Implants / Molecular imaging / Monte Carlo methods / Nuclear Imaging / Positron emission tomography
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https://hal.archives-ouvertes.fr/hal-02458778
Contributor : Inspire Hep <>
Submitted on : Thursday, November 26, 2020 - 12:50:07 PM
Last modification on : Thursday, April 15, 2021 - 3:08:19 PM
Long-term archiving on: : Saturday, February 27, 2021 - 7:05:27 PM

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F. Gensolen, L. Ammour, M. Bautista, J. Heymes, S. Fieux, et al.. MAPSSIC, a communicating MAPS-based intracerebral positrons probe for deep brain imaging in awake and freely-moving rats. 6th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, Jun 2019, Protoroz, Slovenia. pp.09002, ⟨10.1051/epjconf/202022509002⟩. ⟨hal-02458778⟩

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