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First Performance Calculations for the Very High Energy Electron Radiation Therapy Experiment at PRAE

Abstract : The Platform for Research and Applications with Electrons (PRAE) project aims at creating a multidisciplinary R&D platform at the Orsay campus, joining various scientific communities involved in radiobiology, subatomic physics, instrumentation, particle accelerators and clinical research around a high-performance electron accelerator with beam energies up to 70 MeV and later 140 MeV, in order to perform a series of unique measurements and challenging R&D. In this paper we will report the first optics design and performance evaluations of such a multidisciplinary machine, focusing on Very High Energy Electrons (VHEE) innovative Radiation Therapy (RT) applications in particular by allowing Grid and FLASH methodologies, which are likely to represent a major breakthrough in RT. Functional specifications include beam intensities to produce dose rates from 2 Gy/min to 100Gy/sec, beam sizes with diameters from 0.5 mm to 10 cm or more of homogeneous beams and monitoring devices with accuracy in the order of 1-2% for single or multiple beams and single or multiple fractions in biological and ppreclinical applications. High energies (>140 MeV) would be also needed for GRID therapy.
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Angeles Faus-Golfe, Rachel Delorme, Vincent Favaudon, Charles Fouillade, Sophie Heinrich, et al.. First Performance Calculations for the Very High Energy Electron Radiation Therapy Experiment at PRAE. 9th International Particle Accelerator Conference, Apr 2018, Vancouver, Canada. pp.MOPML051, ⟨10.18429/JACoW-IPAC2018-MOPML051⟩. ⟨hal-01871661⟩

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