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Subwavelength far-field ultrasound drug-delivery

Vincent Hingot 1 Marine Bezagu 2, 1 Claudia Errico 1, 2 Yann Desailly 1, 2 Romain Bocheux 1, 2 Mickaël Tanter 1, 2 Olivier Couture 1, 2
1 POM - Physique des Ondes pour la Médecine et la Biologie
INSERM - Institut National de la Santé et de la Recherche Médicale : U979, Institut Langevin ondes et images
Abstract : The theoretical diffraction-limit of resolution for ultrasound imaging has recently been bypassed in-vitro and in-vivo. However, in the context of ultrasound therapy, the precision of therapeutic beams remains bound to the half-wavelength limit. By combining acoustic vaporization of composite droplets and rapid ultrasound monitoring, we demonstrate that the ultrasound drug-delivery can be restricted to a subwavelength zone. Moreover, two release zones closer than the wavelength/4 can be distinguished both optically and through ultrafast ultrasound localization microscopy. This proof-of-concept let us envision the possibility to treat specific tissues more precisely without compromising on the penetration depth of the ultrasound wave.
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Vincent Hingot, Marine Bezagu, Claudia Errico, Yann Desailly, Romain Bocheux, et al.. Subwavelength far-field ultrasound drug-delivery. Applied Physics Letters, American Institute of Physics, 2016, 109 (19), pp.194102. ⟨10.1063/1.4967009⟩. ⟨hal-02481892⟩



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