Plugged into the Ku-DNA hub: The NHEJ network

Abstract : Keywords: DNA damage NHEJ Double-strand breaks Ku Protein interactions network DNA repair machineries Conserved binding motifs a b s t r a c t In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken DNA ends forming a recruiting hub. Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on proteins directly interacting with Ku and on the contact points involved, with a particular accent on the different classes of Ku-binding motifs identified in several Ku partners. An integrated structural model of the core NHEJ network at the synapsis step is proposed.
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Philippe Frit, Virginie Ropars, Mauro Modesti, Jean Baptiste Charbonnier, Patrick Calsou. Plugged into the Ku-DNA hub: The NHEJ network. Progress in Biophysics and Molecular Biology, Elsevier, 2019, ⟨10.1016/j.pbiomolbio.2019.03.001⟩. ⟨hal-02144114⟩

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