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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Sylvie Chastant, Gary England, Oliver Forman, Alexander German, Jan Suchodolski, et al.. Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming. Frontiers in Veterinary Science, 2022, 9, ⟨10.3389/fvets.2022.944821⟩. ⟨hal-03912284⟩
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Romina Via y Rada, Nathalie Daniel, Catherine Archilla, Anne Frambourg, Luc Jouneau, et al.. Identification of the Inner Cell Mass and the Trophectoderm Responses after an In Vitro Exposure to Glucose and Insulin during the Preimplantation Period in the Rabbit Embryo. Cells, 2022, 11 (23), pp. 3766. ⟨10.3390/cells11233766⟩. ⟨hal-03871680⟩
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Marion Bendayan, Emine Sais, Laura Alter, Khadija Fathallah, Monique Jaoul, et al.. For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple’s relationship. Basic and clinical andrology, 2022, 32 (1), pp.3. ⟨10.1186/s12610-022-00153-z⟩. ⟨hal-03599599⟩
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Miriama Štiavnická, Aurélie Chaulot-Talmon, Jean-Philippe Perrier, Petr Hošek, David Kenny, et al.. Sperm DNA methylation patterns at discrete CpGs and genes involved in embryonic development are related to bull fertility. BMC Genomics, 2022, 23 (1), pp.379. ⟨10.1186/s12864-022-08614-5⟩. ⟨hal-03672214⟩
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Valentin Costes, Aurélie Chaulot-Talmon, Eli Sellem, Jean-Philippe Perrier, Anne Aubert-Frambourg, et al.. Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records. Clinical Epigenetics, 2022, 14 (1), pp.54. ⟨10.1186/s13148-022-01275-x⟩. ⟨hal-03654993⟩
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Emilie Derisoud, Orianne Valais, Luc Jouneau, Alexia Durand, Michèle Dahirel, et al.. Nursing in the periconceptional period alters placental gene expression and subsequent foal growth. 18th European Placenta Group IFPA meeting, European Placenta Group, Nov 2022, Jouy en Josas, France. ⟨hal-03903205⟩
References
2 122
Open Access
31 %
Keywords
Spermatogenesis
Uterus
Rabbit
Meiosis
Blastocyst
Chorion
Reproduction
Ruminant
Nuclear transfer
EMBRYO
Pregnancy
Mammary gland
Programmation foetale
DNA methylation
Gene expression
Female
IMAGERIE
PLACENTA
Male
Somatic cell nuclear transfer
GENETIQUE
Embryo transfer
Sheep
Goat
Dohad
Poulain
Sexual dimorphism
Obésité
Alimentation
Embryo
Phénotype
Animal modèle
Pluripotency
Jument
Chromatin
Développement
These
Cattle
Souris
Animal model
NUCLEAR TRANSFER
Oocyte
Cheval
Mare
Conceptus
Epigenetic
Programming
Embryon
RAT
Transcriptome
Oxidative stress
Lapin
Growth
Adult
Development
Obesity
Épigénétique
IMMUNOLOGIE
Trophoblast
Methylation
Cow
Foxl2
Dna methylation
Equine
Endomètre
Mouse
Ovaire
Horse
Ovary
BIOLOGIE DU DEVELOPPEMENT
Nutrition
Implantation
Epigenetics
Humans
Gestation
Sex determination
Foetus
Endometrium
Bovin
Animal models
Méthylation
Bovine
Embryo development
Métabolisme
Mice
GENOMIQUE
Epigénétique
BIOTECHNOLOGIE
Diesel
Progesterone
Développement embryonnaire
Dairy cow
Environment
Fetal programming
Fertility
Fertilité
IMAGE
DOHaD
Sperm
Placenta